骨质疏松症的治疗选择回顾

骨质疏松症:治疗选择回顾翻译:陈贤标

Abstract摘要

Approximately10millionmenandwomenintheU.S.haveosteoporosis,ametabolicbonediseasecharacterizedbylowbonedensityanddeteriorationofbonearchitecturethatincreasetheriskoffractures.Osteoporosis-relatedfracturescanincreasepain,disability,nursinghomeplacement,totalhealthcarecosts,andmortality.Thediagnosisofosteoporosisisprimarilydeterminedbymeasuringbonemineraldensity(BMD)usingnoninvasivedual-energyx-rayabsorptiometry.Osteoporosismedicationsincludebisphosphonates,receptoractivatorofnuclearfactorkappa-Bligandinhibitors,estrogenagonists/antagonists,parathyroidhormoneanalogues,andcalcitonin.EmergingtherapiesutilizingnovelmechanismsincludeacathepsinKinhibitorandamonoclonalantibodyagainstsclerostin.Whileprofessionalorganizationshave

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